Assessment of Silent Neuronal Injury Following Coronary Angiography and Intervention in Patients With Acute Coronary Syndrome

• DOI: 10.1177/1076029614532007
• Publication Date: 2014-05-06T01:37:29Z
• Authors: Ahmet Çağrı Aykan; Tayyar Gökdeniz; Hüseyin Bektaş; Faruk Boyacı; İlker Gül; Engin Hatem; Ezgi Kalaycıoğlu; Turhan Turan; Deniz Çevirme; Şükrü Çelik
• Keywords: Male; Neurons; Middle Aged; Coronary Angiography; Ventricular Function, Left; Cerebrovascular Disorders; 03 medical and health sciences; Percutaneous Coronary Intervention; Postoperative Complications; 0302 clinical medicine; Risk Factors; Phosphopyruvate Hydratase; Humans; Female; Prospective Studies; Acute Coronary Syndrome; Aged

The aim of this study is to evaluate the incidence and predictors silent neuronal injury (SNI) after coronary angiography (CAG) intervention by serial measurement serum neuron-specific enolase (NSE) in patients presented with acute syndrome (ACS). Ninety-eight consecutive ACS underwent CAG were included study. NSE levels significantly increased compared baseline (22.03 ± 27.70 10.08 3.15 consecutively). Left ventricular ejection fraction SNI+ group was lower than that SNI− (43.71% 12.51%, 50.84% 9.34%, P = .002). Maximal creatinine kinase myocardial band, troponin I, SYNTAX score higher those (103.83 99.22, 51.92 78.33, .006; 50.04 66.18, 19.18 30.50, .002; 103.83 .002 successively). performing percutaneous independent SNI ( .009, odds ratio [OR] 1.06, 95% confidence interval [CI] 1.014-1.107, .036, OR 4.262, CI 1.097-16.56). Percutaneous artery lesion complexity may increase risk ACS.