The RELIEF study: Tolerability and efficacy of preservative-free latanoprost in the treatment of glaucoma or ocular hypertension

• DOI: 10.1177/1120672118785280
• Publication Date: 2018-07-12T10:00:00Z
• Authors: Marta Misiuk-Hojlo; Maria Pomorska; Malgorzata Mulak; Marek Rekas; Joanna Wierzbowska; Marek Prost; Jaromir Wasyluk; Wojciech Lubinski; Karolina Podborac...; Wanda Romaniuk; Renata Kinasz; Renata Ortyl-Mark...; Lucyna Mocko; Anna Zaleska-Zmij...; Dariusz Rokicki; Christophe Baudouin
• Keywords: Tolerability; Benzalkonium chloride

Purpose: To assess tolerability and efficacy following a switch from benzalkonium chloride–latanoprost to preservative-free latanoprost in patients with glaucoma or ocular hypertension. Methods: A total of 140 hypertension controlled chloride-latanoprost for at least 3 months were switched treatment latanoprost. Assessments made on days 15, 45, 90 (D15, D45, D90) included best-corrected visual acuity, intraocular pressure, slit lamp examination, fluorescein staining, tear film break-up time, patient symptom evaluation, subjective estimation tolerability. Results: Mean acuity remained unchanged during the study. pressure compared baseline (D0) stable throughout study (D0, 15.9 mmHg (standard deviation = 2.6); D90, 15.3 2.4); p < 0.006). Tear time improved relative 92% D45 93% D90. Moderate-to-severe conjunctival hyperemia was seen 56.8% D0, but this figure decreased 13.7%, 2.2%, 1.6% D15, respectively. Subjective assessment (0–10 scale) indicated improvement change therapy (mean score: 5.3 2.2) D0 versus 1.9 1.7) D90; 0.0001). Conclusion: Preservative-free has same pressure-lowering as chloride–latanoprost, better profile. This may translate into greater control quality life.