The Relation between Baseline HIV Drug Resistance and Response to Antiretroviral Therapy: Re-Analysis of Retrospective and Prospective Studies Using a Standardized Data Analysis Plan

• DOI: 10.1177/135965350000500112
• Publication Date: 2022-04-14T16:25:15Z
• Authors: Victor DeGruttola; Lynn Dix; Richard D'Aquila; Dan Holder; Andrew Phillips; Mounir Ait-Khaled; John Baxter; Philippe Clevenbergh; Scott Hammer; Richard Harrigan; David Katzenstein; Randall Lanier; Michael Miller; Michael Para; Sabine Yerly; Andrew Zolopa; Jeffrey Murray; Amy Patick; Veronica Miller; Steven Castillo; Louise Pedneault; John Mellors
• Keywords: Regimen; HIV drug resistance

To assess the relation between resistance to antiretroviral drugs for treatment of HIV-1 infection and virological response therapy, results from 12 different studies were re-analysed according a standard data analysis plan. These included nine clinical trials three observational cohorts. The primary end-point in our analyses was failure by week 24. Baseline factors that investigated as predictors plasma RNA, number type new regimen, viral susceptibility determined genotyping or phenotyping methods. confirmed importance both genotypic phenotypic drug failure, whether these analysed separately adjusted other baseline confounding factors. In most studies, odds reduced about twofold each additional regimen which patient's virus sensitive methods, two- threefold phenotyping.