Aberrant right subclavian artery: embryology, prenatal diagnosis and clinical significance

• DOI: 10.1177/1742271x211057219
• Publication Date: 2021-11-11T06:36:02Z
• Authors: Rachel Annetta; Debbie Nisbet; Edward O’Mahony; Ricardo Palma-Dias
• Keywords: Trisomy; Abnormality; Clinical Significance

Introduction The right subclavian artery normally arises as the first vessel from brachiocephalic trunk. An aberrant (ARSA) directly aortic arch and crosses behind trachea towards arm. This variant occurs in approximately 1–2% of population; however, frequency increases individuals with chromosomal abnormalities such trisomy 21 22q11.2 microdeletion. Prenatal identification ARSA therefore has a role screening for conditions. Methods Databases were searched studies reporting prenatal ultrasound evaluation its normal fetuses those abnormalities. Results A total 23 evaluated. Feasibility was 85–95%. sonographic detection is best three-vessel view; sagittal coronal imaging may be useful. isolation not found to associated prevalence chromosomally abnormal up 24-fold higher than fetuses, but majority had additional findings, particularly cardiac Conclusions clinically useful marker In isolation, it unlikely pathogenic genetic variants. diagnosis should prompt meticulous assessment Invasive diagnostic testing offered patients non-isolated or presence non-reassuring results other risk factors.