Biphenyl Derivatives from Garcinia Schomburgkiana and the Cytotoxicity of the Isolated Compounds

• DOI: 10.1177/1934578x1300800921
• Publication Date: 2019-03-25T15:33:58Z
• Authors: Chihiro Ito; Takuya Matsui; Eri Noda; Nijsiri Ruangrungsi; Masataka Itoigawa
• Keywords: Garcinia; Jurkat cells; Biphenyl; K562 cells

Study of the chemical constituents stems Garcinia schomburgkiana Pierre (Guttiferae), collected in Thailand, led to isolation and identification five known compounds two new biphenyl derivatives, schomburgbiphenyl A (1) B (2). Six phenolic isolated from this plant were screened for their cell growth inhibition activity using several human leukemia lines. One compound, oblongifolin C (7), showed significant cytotoxic towards Jurkat, NALM6, K562 HPB-ALL cells.