Red cell alloimmunization in a transfused patient population: a study from a tertiary care hospital in north India

• DOI: 10.1179/102453308x343419
• Publication Date: 2008-10-08T02:01:12Z
• Authors: Beenu Thakral; Karan Saluja; Ratti Ram Sharma; Neelam Marwaha
• Keywords: Isoantibodies; Hematology; Transfusion medicine; Tertiary care

Red blood cell (RBC) alloimmunization results from genetic disparity of RBC antigens between donor and recipients. There is a paucity data on the incidence in transfused recipients region studied, as pre-transfusion antibody screening not routinely performed.To assess patient population at tertiary care hospital north India.Antibody was carried out 531 multi-transfused patients prior to crossmatching with commercially available three-cell panel (Diacell; Diamed AG, Cressier-sur-Morat, Switzerland) by tube method, using saline indirect antiglobulin test. Antibody screen-positive samples were analyzed for specificity alloantibody an 11-cell identification (Diapanel; AG). Antigen-negative crossmatch-compatible if clinically significant, whereas insignificant antibodies, anti-human globulin phase issued transfusion.The overall 3.4% (18/531), anti-c being most common (38.8%), followed anti-E (22.2%), anti-M (11.1%), anti-Le(a) anti-D (5.6%), anti-Jk(a) (5.6%) anti-Le(b) (5.6%). The highest observed gastroenterology (4.5%), hematology (3.5%). Of antibodies detected, 16.7% (3/18) Le(a), Le(b) M specificities.The majority alloantibodies detected current study significant. Thus, patients' needs be initiated India ensure safe transfusion practice.