Positive selection of mC46-expressing CD4+ T cells and maintenance of virus specific immunity in a primate AIDS model

• DOI: 10.1182/blood-2013-01-482224
• Publication Date: 2013-05-30T04:52:03Z
• Authors: Patrick M. Younan; Patricia Polacino; John P. Kowalski; Christopher W. Pe...; Nicholas J. Maurice; Nathaniel P. Will...; On Ho; Grant D. Trobridge; Dorothee Von Laer; Martin Prlic; Brian C. Beard; Stephen DeRosa; Shiu-Lok Hu; Hans-Peter Kiem
• Keywords: CD4-Positive T-Lymphocytes; B-Lymphocytes; 0303 health sciences; Recombinant Fusion Proteins; CD4-CD8 Ratio; Cell- and Tissue-Based Therapy; Hematopoietic Stem Cell Transplantation; Simian Acquired Immunodeficiency Syndrome; Gene Expression; Viral Load; Hematopoietic Stem Cells; CD4 Lymphocyte Count; 3. Good health; 03 medical and health sciences; Animals; Simian Immunodeficiency Virus; Viremia; Macaca nemestrina; Antigens, Viral

Key Points Stem cell gene therapy results in enhanced virus-specific immunity and recovery of CD4+ T cells in a nonhuman primate model of AIDS. Gene therapy–mediated protection of stem cells results in a disease state similar to that observed in long-term nonprogressors.