Preclinical efficacy of the synthetic retinoid ST1926 for treating adult T-cell leukemia/lymphoma

• DOI: 10.1182/blood-2014-03-560060
• Publication Date: 2014-07-18T06:39:09Z
• Authors: Hiba El Hajj; Bariaa Khalil; Botheina Ghandour; Rihab Nasr; Sharif Shahine; Akram Ghantous; Rana Abdel-Samad; Ansam Sinjab; Hideki Hasegawa; Mark Jabbour; William W. Hall; Ghazi Zaatari; Ghassan Dbaibo; Claudio Pisano; Ali Bazarbachi; Nadine Darwiche

Key Points The synthetic retinoid ST1926 induces apoptosis of ATL cells and prolongs survival of ATL mice. At the molecular level, ST1926 causes early DNA damage, upregulates p53, and downregulates Tax expression.