Targeting PRMT1-mediated FLT3 methylation disrupts maintenance of MLL-rearranged acute lymphoblastic leukemia

• DOI: 10.1182/blood.2019002457
• Publication Date: 2019-08-09T03:29:07Z
• Authors: Yinghui Zhu; Xin He; Yi-Chun Lin; Haojie Dong; Lei Zhang; Xianwei Chen; Zhihao Wang; Yudao Shen; Min Li; Hanying Wang; Jie Sun; Le Xuan Nguyen; Han Zhang; Wenjuan Jiang; Yanzhong Yang; Jianjun Chen; Markus Müschen; Chun-Wei Chen; Marina Y. Konopleva; Weili Sun; Jian Jin; Nadia Carlesso; Guido Marcucci; Yun Luo; Ling Li
• Keywords: Acute lymphocytic leukemia

Key Points High PRMT1 expression maintains MLL-r ALL cell survival and growth by regulating FLT3 methylation at R972/973. PRMT1 inhibition enhances ablation of MLL-r ALL by tyrosine kinase inhibitor treatment.