Carbon monoxide affects electrical and contractile activity of rat myocardium

• DOI: 10.1186/1423-0127-18-40
• Publication Date: 2011-06-15T18:16:00Z
• Authors: Denis V Abramochkin; Nail N Haertdinov; Maria V Porokhnya; Andrew L Zefirov; Gusel F Sitdikova
• Keywords: Male; 0301 basic medicine; Endocrinology, Diabetes and Metabolism; Clinical Biochemistry; 610; Action Potentials; Protoporphyrins; 03 medical and health sciences; Animals; Ventricular Function; Pharmacology (medical); Rats, Wistar; Molecular Biology; Biochemistry, medical; Carbon Monoxide; Research; Myocardium; R; Heart; Cell Biology; Atrial Function; Myocardial Contraction; Rats; 3. Good health; Electrophysiology; Heme Oxygenase (Decyclizing); Medicine; Signal Transduction

Carbon monoxide (CO) is a toxic gas, which also acts in the organism as neurotransmitter. It generated by-product of heme breakdown catalyzed by oxygenase. We have investigated changes electrical and contractile activity isolated rat atrial ventricular myocardium preparations under influence CO. Standard microelectrode technique was used for intracellular registration myocardium. Contractions myocardial stripes were registered via force transducer. CO (10-4 - 10-3 M) caused prominent decrease action potential duration (APD) working well significant acceleration sinus rhythm. In addition reduced contractions other parameters activity. Inhibitor oxygenase zinc protoporphyrin IX exerts opposite effects: prolongation potential, reduction rhythm rate enhancement function. Therefore, endogenous CO, may be heart due to presence active oxygenase, likely exert same effects exogenous applied perfusing medium. induced shortening while produced effect. Thus, or carbon act an important regulator cardiac