Changes in microRNA expression profile in hippocampus during the acquisition and extinction of cocaine-induced conditioned place preference in rats

• DOI: 10.1186/1423-0127-20-96
• Publication Date: 2013-12-20T14:05:50Z
• Authors: Chun-Lin Chen; Hailin Liu; Xiaowei Guan
• Keywords: Conditioned place preference; Extinction (optical mineralogy)

MicroRNA (miRNA) emerges as important player in drug abuse. Yet, their expression profile neurological disorder of cocaine abuse has not been well characterized. Here, we explored the changes miRNA rat hippocampus following repeated exposure and subsequent abstinence from treatment. Conditioned place preference (CPP) procedure was used to assess acquisition extinction cocaine-seeking behavior rats. MiRNA microarray performed examine miRNAs levels hippocampus. Quantitative RT-PCR conducted further confirm results study. Finally, bioinformatic predictions were made suggest potential target genes cocaine-responsive this array found that 34 changed while acquiring CPP 42 altered after cocaine-induced extinguished, compared normal controls. The findings qRT-PCR study support analysis. current demonstrated dynamic during CPP. Some which have previously reported be involved brain disorders abuse, including miR-133b, miR-134, miR-181c, miR-191, miR-22, miR-26b, miR-382, miR-409-3p miR-504, These may extend our understanding regulatory network underlying provide new targets for future treatment