The choroid plexus response to a repeated peripheral inflammatory stimulus

• DOI: 10.1186/1471-2202-10-135
• Publication Date: 2009-11-19T07:13:53Z
• Authors: Fernanda Marques; João C Sousa; Giovanni Coppola; Daniel H Geschwind; Nuno Sousa; Joana A Palha; Margarida Correia...
• Keywords: Stimulus (psychology)

Abstract Background Chronic systemic inflammation triggers alterations in the central nervous system that may relate to underlying inflammatory component reported neurodegenerative disorders such as multiple sclerosis and Alzheimer's disease. However, it is far from being understood whether how peripheral contributes induce brain response illnesses. As part of barriers separate blood brain, choroid plexus conveys immune signals into largely through composition cerebrospinal fluid. Results In present study we investigated mouse gene expression profile, using microarray analyses, a repeated stimulus induced by intraperitoneal administration lipopolysaccharide every two weeks for period three months; mice were sacrificed 3 15 days after last injection. The data show displays sustained stimuli altering profile several genes. From total 24,000 probes, 369 are up-regulated 167 down-regulated injection, while at number decreases 98 128, respectively. pathways displaying most significant changes include those facilitating entry cells fluid, participating innate infection. Conclusion These observations contribute better understanding pave way their impact on progression which known be implicated.