Differential regulation of amphetamine-induced serotonergic and dopaminergic efflux by syntaxin 1A

• DOI: 10.1186/1471-2210-11-s2-a38
• Publication Date: 2011-09-06T06:37:53Z
• Authors: Therese Montgomery; Sonja Sucic; Thomas Steinkellner; Michael Freissmuth; Harald Sitte
• Keywords: Neurotransmitter transporter

Background The plasma membrane serotonin transporter (SERT) is a key regulator of synaptic serontonergic neurotransmission and major target both antidepressents psychostimulant drugs abuse. pre-synaptic soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) syntaxin 1A has been reported to modulate the intrinsic activity multiple monoamine neurotransmitter transporters in vitro ex vivo. However, contrast dopamine (DAT) little know its effect on SERT-dependent amphetamine-mediated efflux neuronal cells. Thus, purpose this study was examine specific effects SERT function regulation by common