Dedifferentiated liposarcomas: evaluation of the prognostic and therapeutic factors in the elderly patient

• DOI: 10.1186/1471-2318-10-s1-a1
• Publication Date: 2010-05-19T18:17:28Z
• Authors: C Amodeo; P Caglia’; A Tracia; S Costa; V Russo; B Lucifora; L Borzi’; E Zappulla
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Geriatrics; RC952-954.6; Geriatrics and Gerontology; Meeting abstract; 3. Good health

BackgroundLiposarcomas (LPS) are rare tumors accounting approxi-mately for 19% of adult soft-tissue tumors [1]. The mostrecent classification of the WHO divides liposarcomasinto 3 main clinicopatological and genetic subtypes:myxoid/round cells liposarcoma, well differentiated /dedifferentiated liposarcoma and pleomorphic liposar-coma [2]. The importance of a total macroscopicalresection to perform an oncologically correct operationis well known, so that it is often necessary to removeone or more adjoining organs with the purpose of redu-cing the risk of local secondary recurrences [3].Materials and methodsWe present the case of an 88-year-old woman with alarge abdominal swelling. The TC of the abdomenshows the spleen moved upward (Figure. 1). The lefthemiabdomen is filled by an expansive formation almost20 cm wide in diameter, made partly of a solid compo-nent and partly cystic-like. The pancreas is totallyagainst the gallbladder. It does not seem possible toremove the back wall of the spleen from the swelling.(Figure 2).We decide to perform surgery. The neoplasia is incontinuity with the tail of the pancreas, so a distal pan-creasectomy and splenectomy is performed. Definitivehistological examination: dedifferentiated liposarcoma ofhigh degree.ResultsAfter surgical resection ofthe primitive liposarcoma,factors determining the probability of recurrence and