RETRACTED ARTICLE: Peripheral blood mono-nuclear cells implantation in patients with peripheral arterial disease: a pilot study for clinical and biochemical outcome of neoangiogenesis

• DOI: 10.1186/1471-2482-12-s1-s1
• Publication Date: 2013-08-05T09:47:55Z
• Authors: Bruno Amato; Rita Compagna; Gianni Antonio De...; Giovanni Martino; Tommaso Bianco; Guido Coretti; Roberto Rossi; Antonio Braucci; Giovanni Aprea; Pio Zeppa; Alessandro Puzziello; Claudio Terranova
• Keywords: Claudication; Intermittent claudication

Substantial progresses in the management of peripheral arterial disease (PAD) have been made past two decades. Progress understanding endothelial-platelet interaction during health and state has resulted better antiplatelet drugs that can prevent platelet aggregation, activation thrombosis angioplasty stenting. A role physiological pathological angiogenesis adults recently shown bone marrow–derived circulating endothelial progenitors (BM-DCEPs) identified blood. These findings paved way for development therapeutic neovascularization techniques using progenitors. This pilot study includes five patients, aged 60 to 75, with a history claudication recruited from September 2010 February 2011 at A.O.U. Federico II Naples. PBMNCs implanted three times limb worst ABI value all patients included study. The clinical follow up was performed subsequent 12 months beginning treatment. In four there regression ulcerative lesions. One patient's condition improved after first implantation but later did not respond further treatments. All achieved pain relief as judged by numeric scale. Pain remained satisfactory one year. gradually returned pre-treatment level patients. referred an ameliorating their quality life expressed even improvement free walking distance. improvements are reflected also intra-arterial digital subtraction angiography (IADSA) shows vascularization. data this suggest efficacy BM-DCEPs terms vascularization affected Peripheral Arterial Disease. Nevertheless double-blind placebo-controlled is needed confirm our findings.