Resveratrol ameliorates liver fibrosis induced by nonpathogenic Staphylococcus in BALB/c mice through inhibiting its growth

• DOI: 10.1186/s10020-022-00463-y
• Publication Date: 2022-05-04T11:02:58Z
• Authors: Zhiqin Li; Jianxia Dong; Meng Wang; Jingya Yan; Yushu Hu; Yang Liu; Yajie Pan; Hua Li
• Keywords: Staphylococcus xylosus

Abstract Background The altered gut microbiota is implicated in the pathogenesis of liver fibrosis. Resveratrol a candidate for treatment fibrosis, which could ameliorate dysregulation mice. This study aimed to clarify role and mechanism resveratrol during Methods A mouse model fibrosis induced by CCl 4 was conducted assess effect on changes fibrotic mice after intervention were assessed using 16S ribosomal RNA sequencing. investigated Sirius red staining, immunohistochemical assay, bacterial translocation (BT), EUB338 fluorescence situ hybridization, immunofluorescence, trans-epithelial electrical resistance analysis paracellular permeability analysis. Results relieved -induced Besides, restrained Staphylococcus_lentus Staphylococcus_xylosus mice, facilitated occurrence BT cultures them enhanced intestine. vivo assay corroborated that excessive canceled protecting or alone had limited impact injury normal Conclusion ameliorated restraining growth .