Genome-wide association and genomic prediction of breeding values for fatty acid composition in subcutaneous adipose and longissimus lumborum muscle of beef cattle

• DOI: 10.1186/s12863-015-0290-0
• Publication Date: 2015-11-20T23:52:53Z
• Authors: Liuhong Chen; Chinyere Ekine-Dz...; Michael Vinsky; John Basarab; Jennifer Aalhus; Mike E. R. Dugan; Carolyn Fitzsimmons; Paul Stothard; Changxi Li
• Keywords: Genome-wide Association Study; Beef Cattle

Background: Identification of genetic variants that are associated with fatty acid composition in beef will enhance our understanding host influence on the trait and also allow for more effective improvement profiles through genomic selection marker-assisted diet management.In this study, 81 83 traits were measured subcutaneous adipose (SQ) longissimus lumborum muscle (LL), respectively, from 1366 purebred crossbred steers heifers genotyped Illumina BovineSNP50 Beadchip.The objective was to conduct genome-wide association studies (GWAS) evaluate accuracy prediction using best linear unbiased (GBLUP) Bayesian methods.Results: In total, 302 360 significant SNPs spanning all autosomal chromosomes identified be SQ LL tissues, respectively.Proportions total variance explained by individual ranged 0.03 11.06 % SQ, 0.005 24.28 muscle.Markers relatively large effects located near synthase (FASN), stearoyl-CoA desaturase (SCD), thyroid hormone responsive (THRSP) genes.For majority studied, low (<0.40).Relatively high accuracies (> = 0.50) achieved 10:0, 12:0, 14:0, 15:0, 16:0, 9c-14:1, 12c-16:1, 13c-18:1, health index (HI) LL, 10 t,12c-18:2, 11 t,13c + 11c,13 t-18:2 SQ.The method performed similarly as GBLUP most but substantially better affected GWAS.Conclusions: Fatty is influenced a few genes major many smaller effects.With current training population size marker density, has potential predict breeding values cattle at moderate acids have heritability.