The genomic features of parasitism, Polyembryony and immune evasion in the endoparasitic wasp Macrocentrus cingulum

• DOI: 10.1186/s12864-018-4783-x
• Publication Date: 2018-05-30T09:14:01Z
• Authors: Chuanlin Yin; Meizhen Li; Jian Hu; Kun Lang; Qiming Chen; Jinding Liu; Dianhao Guo; Kang He; Yipei Dong; Jiapeng Luo; Zhenkun Song; James R. Walters; Wenqing Zhang; Fei Li; Xuexin Chen
• Keywords: Cingulum (brain)

Parasitoid wasps are well-known natural enemies of major agricultural pests and arthropod borne diseases. The parasitoid wasp Macrocentrus cingulum (Hymenoptera: Braconidae) has been widely used to control the notorious insect Ostrinia furnacalis (Asian Corn Borer) O. nubilalis (European corn borer). One striking phenomenon exhibited by M. is polyembryony, formation multiple genetically identical offspring from a single zygote. Moreover, employs passive parasitic strategy preventing host's immune system recognizing embryo as foreign body. Thus, embryos evade not encapsulated host hemocytes. Unfortunately, mechanism both polyembryony evasion remains largely unknown. We report genome cingulum. Comparative genomics analysis other 11 insects were conducted, finding some gene families with apparent expansion or contraction which might be linked behaviors we present evidence that microRNA miR-14b regulates polyembryonic development targeting c-Myc Promoter-binding Protein 1 (MBP-1), histone-lysine N-methyltransferase 2E (KMT2E) segmentation protein Runt. In addition, Hemomucin, an O-glycosylated transmembrane protein, protects endoparasitoid larvae being Motif domain showed only hemomucin in two endoparasitoids, Venturia canescens, possessing ability intact mucin similar O-glycosylation patterns, indicating key factor modulating evasion. participates regulation development, confers this wasp. These findings provide new insights into