Protein acetylation in mitochondria plays critical functions in the pathogenesis of fatty liver disease

• DOI: 10.1186/s12864-020-06837-y
• Publication Date: 2020-06-26T04:37:20Z
• Authors: Zhang Le-tian; Hu Cheng-zhang; Zhang Xuan; Qin Zhang; Yan Zhen-gui; Wei Qing-qing; Wang Sheng-xuan; Xu Zhong-jin; Li Ran-ran; Liu Ting-jun; Su Zhong-qu; Wang Zhong-hua; Shi Ke-rong
• Keywords: Fatty Acid Metabolism; Pathogenesis

Abstract Background Fatty liver is a high incidence of perinatal disease in dairy cows caused by negative energy balance, which seriously threatens the postpartum health and milk production. It has been reported that lysine acetylation plays an important role substance metabolism. Predictably, most metabolic processes liver, as vital organ, are subjected to acetylation. Comparative acetylome study were used quantify hepatic tissues from severe fatty group normal group. Combined with bioinformatics analysis, this provides new insights for modification cows. Results We identified 1841 differential sites on 665 proteins. Among them, 1072 393 proteins quantified. Functional enrichment analysis shows higher acetylated significantly enriched pathways, while lower pathways related immune response, such drug metabolism cancer. proteins, many mitochondrial be interacting multiple involving lipid Furthermore, potential HADHA, ACAT1, EHHADH, may regulatory factors through development possible therapeutic targets NAFLD human beings. Conclusion This provided comprehensive profile cows, revealed biological associated protein occurred mitochondria, involved regulation pathogenesis disease. predicted essential regulators during The work would contribute understanding NAFLD, inspire strategies NAFLD.