Impact of coprophagy prevention on the growth performance, serum biochemistry, and intestinal microbiome of rabbits

• DOI: 10.1186/s12866-023-02869-y
• Publication Date: 2023-05-10T06:06:53Z
• Authors: Zhitong Wang; Hui He; Mengjuan Chen; Mengke Ni; Dongdong Yuan; Hanfang Cai; Zhi Chen; Ming Li; Huifen Xu
• Keywords: Cecum; Ruminococcus; Caecum; Microecology; Bandicoot; Eubacterium

Abstract Background Coprophagy plays a vital role in maintaining growth and development many small herbivores. Here, we constructed coprophagy model by dividing rabbits into three groups, namely, control group (CON), sham-coprophagy prevention (SCP), (CP), to explore the effects of on performance cecal microecology rabbits. Results showed that CP treatment decreased feed utilization Serum total cholesterol triglyceride were remarkably lower than those other two groups. Furthermore, destroyed cecum villi reduced content short-chain fatty acids (SCFAs) contents. Gut microbiota profiling significant differences phylum genus composition microorganisms among At level, abundance Oscillospira Ruminococcus significantly group. Enrichment analysis metabolic pathways up-regulated differential pathway ( PWY-7315 , dTDP-N-acetylthomosamine biosynthesis) compared with CON Correlation serum biochemical parameters positively correlated Sutterella Butyricimonas but negatively Oxalobacte Desulfovibrio . Meanwhile, Parabacteroidesde was concentration butyric acid cecum. Conclusions In summary, had negative biochemistry gut microbiota, ultimately decreasing The findings provide evidence for further revealing biological significance herbivorous mammals.