Acute coronary syndrome and acute kidney injury: role of inflammation in worsening renal function

• DOI: 10.1186/s12872-017-0640-0
• Publication Date: 2017-07-26T13:05:42Z
• Authors: Jorge Ortega-Hern...; Rashidi Springall; Fausto Sánchez-Muñoz; Julio-C. Arana-Ma...; Héctor González-P...; Rafael Bojalil
• Keywords: Blood urea nitrogen

Acute Kidney Injury (AKI), a common complication of acute coronary syndromes (ACS), is associated with higher mortality and longer hospital stays. The role cytokines other mediators unknown in AKI induced by an ACS (ACS-AKI), leading to several unanswered questions. worsening renal function usually seen as dichotomous phenomenon instead dynamic change, so evaluating changes the time may provide valuable information ACS-AKI setting. aim this study was explore inflammatory factors de novo kidney injury cardiac secondary ACS.One hundred four consecutive patients were initially included on admission Coronary Unit Instituto Nacional Cardiología Mexico City, from February May 2016, before any invasive procedure, imaging study, diuretic or anti-platelet therapy. White blood count, hemoglobin, NT-ProBNP, troponin I, C-reactive protein, albumin, glucose, Na+, K+, urea nitrogen (BUN), total cholesterol, HDL, LDL, triglycerides, creatinine (Cr), endothelin-1 (ET-1), leukotriene-B4, matrix metalloproteinase-2 -9, tissue inhibitor metalloproteinases-1, resolvin-D1 (RvD1), lipoxin-A4 (LXA4), interleukin-1β, -6, -8, -10 measured. We finally enrolled 78 patients, subsequently we identified 15 ACS-AKI. Correlations obtained Spearman rank test. Low-rank regression, splines regressions, also protein-protein/chemical interactions pathways analyses networks performed.Positive correlations ΔCr found BUN, Cr, GRACE score, IL-1β, IL-6, NT-ProBNP age, negative systolic pressure, mean-BP, diastolic-BP LxA4. In regression IL-10 RvD1 had positive non-linear associations ΔCr. ET-1 association. Significant NT-proBNP, WBC, body mass index, GRACE, SBP, mean-BP Hb.Inflammation its components play important ACS. IL-10, ET-1, TnI, LxA4 represent that might be crossroads for physiopathological involved "de injury".