Elevated exhaled acetone concentration in stage C heart failure patients with diabetes mellitus

• DOI: 10.1186/s12872-017-0713-0
• Publication Date: 2017-11-16T08:58:28Z
• Authors: Tetsuro Yokokawa; Takamasa Sato; Satoshi Suzuki; Masayoshi Oikawa; Akiomi Yoshihisa; Atsushi Kobayashi; Takayoshi Yamaki; Hiroyuki Kunii; Kazuhiko Nakazato; Hitoshi Suzuki; Shu-ichi Saitoh; Takafumi Ishida; Akito Shimouchi; Yasuchika Takeishi
• Keywords: Angiology

Breath acetone is a noninvasive biomarker of heart failure; however, its significance in failure patients with diabetes mellitus has yet to be clarified. The objective this study investigate whether exhaled concentration mellitus.This prospectively included 35 diabetic stage C and 20 or at risk (stage A B). Exhaled breath was collected after an overnight fast.The group had significantly higher brain natriuretic peptide levels, larger left ventricular diameter, lower ejection fraction, more frequent use β-blocker, compared the B group. concentrations than (p = 0.013). correlated total ketone bodies (r 0.588, p < 0.001) 0.415, 0.002).Stage have elevated concentrations. could mellitus.