Hyperlipidemia and hypertension have synergistic interaction on ischemic stroke: insights from a general population survey in China

• DOI: 10.1186/s12872-022-02491-2
• Publication Date: 2022-02-13T21:02:28Z
• Authors: Chang Wang; Zhi Du; Ning Ye; Chuning Shi; Songyue Liu; Danxi Geng; Yingxian Sun
• Keywords: Stroke; Hyperlipidemia; Angiology

Abstract Background Hyperlipidemia (HLP) and hypertension (HTN) are both independent risk factors for ischemic stroke. This study aimed to assess whether HTN HLP have a synergistic effect on the of Methods Between January August 2013, 11,695 subjects in rural areas northeastern China were enrolled. The additive multiplicative scales used evaluate interaction. Results prevalence stroke was 5.7%. Using healthy group (without or HLP) as reference group, with had higher (odds ratio [OR]: 3.369, 95% confidence interval [CI]: 2.579–4.402), this OR greater than that only (OR: 1.995, CI 1.526–2.610) 1.321, 0.937–1.862) (adjusting age, sex, race, education level, family income, current smoking drinking status, physical activity, body mass index, diabetes, history stroke, atrial fibrillation). Regarding scale, relative excess due interaction 1.053, 0.458–1.648) positive after adjusting confounders. Moreover, attributable proportion 31.3%, which means 31.3% total between HLP. Furthermore, index (S) 1.8 (95% 1.157–2.801), also indicates significant confounders 2.163, 1.817–2.575). Conclusion results suggest is significantly sum their effects. quantification combined should help promote blood pressure lipid levels among general population.