Fecal microbiota transplantation for ulcerative colitis: a prospective clinical study

• DOI: 10.1186/s12876-019-1010-4
• Publication Date: 2019-07-04T13:57:56Z
• Authors: Yan Tian; Yan Zhou; Sisi Huang; Jun Li; Kui Zhao; Xiaohui Li; Xiangchen Wen; Xiao-an Li
• Keywords: Erythrocyte sedimentation rate

Fecal microbiota transplantation may contribute to disease remission in ulcerative colitis; however, the factors that determine effects of treatment remain unknown. The aim present study was prospectively investigate clinical efficacy fecal patients with colitis and identify bacterial signatures associated remission. A total 20 were included this prospective uncontrolled study. All underwent gastroscopy five times, once every 3 weeks. Clinical indices used assess transplantation, as well Mayo score, a score evaluate extent intestinal mucosal lesions colitis. changes flora detected by 16S ribosomal RNA-sequencing, relationship between analyzed. After treatment, index scores for diarrhea, abdominal pain, blood stool decreased significantly (p < 0.05). Erythrocyte sedimentation rate C-reactive protein levels had not changed significantly; significantly. In addition, RNA-sequencing revealed diagnosed different from donors. has potential therapeutic value it abundance improves mucous membrane disease. trial retrospectively registered ClinicalTrials.gov ( NCT03016780 ) on January 11th, 2017.