Nerve growth factor and Tropomyosin receptor kinase A are increased in the gastric mucosa of patients with functional dyspepsia

• DOI: 10.1186/s12876-019-1133-7
• Publication Date: 2019-12-19T17:04:25Z
• Authors: Haitao Shi; Shanshan Zhu; Bin Qin; Lianli Wang; Juan Yang; Guolong Lu; Fei Dai
• Keywords: Epigastric pain

Nerve growth factor (NGF) and enteric glial cells (EGCs) are associated with visceral hypersensitivity gastrointestinal motility disorder, which may represent the pathogenesis of functional dyspepsia (FD). This study aimed to investigate expression NGF, its high affinity receptor tropomyosin kinase A (TrkA) EGC activation marker fibrillary acidic protein (GFAP) in gastric mucosa patients FD association these proteins dyspeptic symptoms.Gastric mucosal biopsies taken from 27 (9 epigastric pain syndrome (EPS) patients, 7 postprandial distress (PDS) 11 EPS overlap PDS patients) 26 control subjects were used for analysis. The TrkA GFAP was examined, symptoms, including pain, fullness, early satiation burning, analysed.The levels TrkA, significantly higher group, group than healthy group. There no significant difference between subgroups. colocalized GFAP, indicated that localized EGCs, EGCs Changes positively correlated fullness but had relationship burning.The increased might be involved pathophysiology symptom perception.