Small intestinal microbiota composition and the prognosis of infants with ileostomy resulting from distinct primary diseases

• DOI: 10.1186/s12876-020-01366-0
• Publication Date: 2020-07-13T12:06:02Z
• Authors: Tian Qian; Haitao Zhu; Li Zhu; Chao Chen; Chun Shen; Rong Zhang
• Keywords: Veillonella; Faecalibacterium prausnitzii

Abstract Background Studies of microbiota composition infants with small intestinal ostomy due to various etiologies are limited. Here, we characterized the neonates ileostomy resulting from distinct primary diseases. Methods Fifteen patients necrotizing enterocolitis, eight meconium peritonitis, and seven Hirschsprung’s disease were included in study. The caused by these diseases was studied. Results Microbial diversity neonatal fluid generally low, dominated members Proteobacteria Firmicutes phyla. At genus level, most abundant Klebsiella , Escherichia-Shigella Streptococcus Clostridium sensu stricto 1, Enterococcus Lactobacillus . Veillonella related carbohydrate metabolism immunity, breastfeeding can increase proportion potentially beneficial bacteria. Bifidobacterium group higher than that non-breastfeeding group, incidence colitis sepsis reduced group. increased decreased compared non- but there no significant difference. body weight observed be Conclusions Excessive low abundance Faecalibacterium suggests is an unhealthy state after ileostomy. However, species frequently present, suggesting expansion bacteria might assist development immune system surgery.