Hepatitis B virus-associated hepatocellular carcinoma in South Africa in the era of HIV

• DOI: 10.1186/s12876-020-01372-2
• Publication Date: 2020-07-13T12:06:02Z
• Authors: Tongai Gibson Map...; Richard H. Glashoff; Hannali Vermeulen; Barbara Robertson; Sean Burmeister; Marc Bernon; Jones Omoshoro-Jones; Paul Ruff; Alfred I. Neugut; Judith S. Jacobson; Wolfgang Preiser; Monique I. Andersson
• Keywords: Hepatitis B

Abstract Background Patients co-infected with hepatitis B virus (HBV) and the human immunodeficiency (HIV) are at risk of developing hepatocellular carcinoma (HCC). In sub-Saharan Africa, overlap between high HIV HBV prevalence may increase incidence HCC. This study investigated impact HBV/HIV co-infection on age presentation survival Methods Ethical approval was obtained to recruit, following informed written consent, patients diagnosed HCC oncology units four South African hospitals. Between December 2012 August 2015, newly were recruited provided demographic clinical data blood specimens. tested for HBV, C (HCV) HIV. Survival available a subset patients. Results Of 107 cases, 83 (78%) male. Median 46 years (range 18 90 years), 68/106 (64%) HBsAg-positive, 22/100 (22%) infected. Among surface antigen (HBsAg)-positive 18/66 (27%) HIV-infected compared 3/34 (9%) among those that HBsAg-negative ( p = 0.04). A greater proportion cases female than mono-infected (6/18, 33% vs 6/47, 13%; 0.005). addition, females presented younger mean (36.8 years) women (50.5 0.09). 82 days 181 without 0.15). Conclusions is an important complication in HIV/HBV infected patient. HIV-positive HIV-negative patients, this effect appears be women. These provide more evidence supporting call address. as cause morbidity mortality patient population. (281 words).