The prognostic significance of tumor-specific growth factor in colorectal cancer: an observation study

• DOI: 10.1186/s12876-025-03902-2
• Publication Date: 2025-04-21T19:42:12Z
• Authors: Yanjun Lu; Xinxuan Zhao; Haiyi Liu; Yixun Zhang; Linghong Guo; Lichun Wang

The correlation between tumor-specific growth factor (TSGF) and the prognosis of colorectal cancer (CRC)has not been extensively studied. Research was designed to evaluate potential TSGF as a predictive marker for patients with CRC. serum quantified stratified into elevated/normal groups based on established threshold detected using rate method. log-rank test employed survival analysis 3-year overall (OS). Prognostic independence verified through Cox proportional hazards model. receiver operating characteristic (ROC) curves were plotted assess clinical application value TSGF. A total 2223 incorporated in our study. revealed that elevated levels associated poorer multivariate demonstrated an independent prognostic factor. signature covering T staging, N CEA, CA199 superior capability Area Under Curve (AUC) (Delong's p = 0.025). is correlating OS stage I-III CRC patients. Moreover, new including can effectively improve evaluation CRC, thereby contributing precision medication.