Differential associations of visual memory with hippocampal subfields in subjective cognitive decline and amnestic mild cognitive impairment

• DOI: 10.1186/s12877-022-02853-7
• Publication Date: 2022-02-24T13:02:31Z
• Authors: Yanlu Huang; Lin Huang; Yifan Wang; Yuchen Liu; Chun-Yi Zac Lo; Qihao Guo
• Keywords: Subiculum; Memory Impairment

Abstract Background Although previous studies have demonstrated that the hippocampus plays a role in verbal memory, of hippocampal subfields visual memory is uncertain, especially those with preclinical Alzheimer's disease (AD). This study aimed to examine relationships between subfield volumes and SCD (subjective cognitive decline) aMCI (amnestic mild impairment). Methods The sample included 47 patients, 62 51 normal controls (NCs) was recruited from Shanghai Jiao Tong University Affiliated Sixth People's Hospital. Visual measured by subtests BVMT-R (Brief Visuospatial Memory Test-Revised), PLT (Pictorial Learning Test), DMS (Delayed Matching Sample), PAL (Paired Associates Learning). Hippocampal were estimated using FreeSurfer software (version 6.0). We modeled association relative (dividing total intracranial volume) Pearson's correlation linear regression. Results Compared NC group, patients did not find any subregion atrophy, group found atrophy CA1, molecular layer, subiculum, GC-ML-DG, CA4, CA3. After adjusting for covariates (age, sex, APOE ε4 status) FDR (false discovery rate) correction p (q values) < 0.05, delay matching scores significant negatively associated presubiculum (r = -0.399, q 0.024); CA3 -0.378, 0.048); immediate recall positively GC-ML-DG 0.360–0.374, 0.036). Stepwise regression analysis confirmed association. Conclusions Our results indicate different specific aMCI. correlations involved more as decline. Whether these associations predict future progression needs dynamic longitudinal studies.