Hepatitis C and not Hepatitis B virus is a risk factor for anti-tuberculosis drug induced liver injury

• DOI: 10.1186/s12879-016-1344-2
• Publication Date: 2016-02-01T15:12:11Z
• Authors: Wan Soo Kim; Sang Soo Lee; Chang Min Lee; Hong Jun Kim; Chang Yoon Ha; Hyun Jin Kim; Tae Hyo Kim; Woon Tae Jung; Ok Jae Lee; Jeong Woo Hong; Hyun Seon You; Hyun Chin Cho
• Keywords: Hepatitis B; Liver function; Hepatitis C; Medical microbiology

The risk of anti-tuberculosis (TB) drug-induced liver injury (DILI) in patients with chronic viral hepatitis (CVH) is not clear. aim this study was to investigate incidence and factors associated TB DILI CVH non-CVH patients. Retrospectively, a total 128 who received anti-TB medication from January 2005 February 2014 were reviewed. Among these, 83 had B virus (HBV), 41 C (HCV) 4 dual co-infected (HBV + HCV) 251 selected as the controls. There no human immunodeficiency Risk for analyzed using cox regression analysis. significantly higher HCV group (13/41 [31.7 %], p < 0.001) HBV groups (3/4 [75.0 = 0.002) compared control (25/251 [10.0 %]). transient function impairment than (18/83 [21.7 %] vs. 27/251 [10.8 0.010), but (11/83 [13.3 25/251 0.400). In patients, HCV, co-infection, older age, baseline abnormality independent DILI. It recommended carefully monitor or HBV/HCV abnormality.