Clinical feature of severe fever with thrombocytopenia syndrome (SFTS)-associated encephalitis/encephalopathy: a retrospective study

• DOI: 10.1186/s12879-021-06627-1
• Publication Date: 2021-09-03T13:03:53Z
• Authors: Ying Xu; Mingran Shao; Ning Liu; Danjiang Dong; Jian Tang; Qin Gu
• Keywords: Phlebovirus; Brain Diseases; China; Severe Fever with Thrombocytopenia Syndrome; Research; Bacteremia; Infectious and parasitic diseases; RC109-216; Encephalopathy; Severe fever with thrombocytopenia syndrome; 3. Good health; Vasopressor; 03 medical and health sciences; Cerebrospinal fluid; 0302 clinical medicine; Encephalitis; Humans; Retrospective Studies

Abstract Background/objective Severe fever with thrombocytopenia syndrome (SFTS) cause encephalitis/encephalopathy, but few reports were available. We aimed to investigate the incidence of encephalitis/encephalopathy in SFTS patients and summarize clinical characteristics, laboratory findings imaging features. Methods conducted a retrospective review all confirmed admitted Nanjing Drum Tower Hospital, tertiary hospital City, China, between January 2016 July 2020. The divided into two groups according whether they had encephalitis/encephalopathy: group non- group. Clinical data, findings, treatments outcomes these collected analyzed. Results A total 109 included, whom 30 (27.5 %) developed encephalitis/encephalopathy. In-hospital mortality (43.3 was higher than non-encephalitis/encephalopathy (12.7 %). Univariate logistic regression showed that cough, wheezing, dyspnoea, respiratory failure, vasopressors use, bacteremia, invasive pulmonary aspergillosis (IPA) diagnoses, PCT > 0.5 ug/L, CRP 8 mg/L, AST 200 U/L serum amylase level 80 risk factors for development patients. Multivariate analysis identified mg/L as independent predictors encephalitis/ encephalopathy Conclusions SFTS-associated has high morbidity mortality. it necessary strengthen screening CSF testing brain after admission who symptoms ug/L or should be warned progress encephalopathy.