Prolonged viral shedding of SARS-CoV-2 and related factors in symptomatic COVID-19 patients: a prospective study

• DOI: 10.1186/s12879-021-07002-w
• Publication Date: 2021-12-27T12:03:12Z
• Authors: Hui Long; Jing Zhao; Hao-Long Zeng; Qing-Bin Lu; Li-Qun Fang; Qiang Wang; Qing-Ming Wu; Wei Liu
• Keywords: Viral Shedding; Medical microbiology

The temporal relationship between SARS-CoV-2 and antibody production clinical progression remained obscure. aim of this study was to describe the viral kinetics symptomatic patients with infection identify factors that might contribute prolonged shedding.Symptomatic COVID-19 were enrolled in two hospitals Wuhan, China, from whom respiratory samples collected measured for loads consecutively by reverse transcriptase quantitative PCR (RT-qPCR) assay. shedding pattern delineated relate epidemiologic information.Totally 2726 703 quantified. at highest level during initial stage after symptom onset, which subsequently declined time. median time negativity nasopharyngeal test 28 days, significantly longer older age (> 60 years old), female gender those having interval onset hospital admission 10 days). multivariate Cox regression model revealed significant effect (HR 0.73, 95% CI 0.55-0.96), 0.72, 0.55-0.96) 0.44, 0.33-0.59) on negativity. IgM titer higher low group 41-60 days onset. At population level, average early than late outbreak periods.The observed patients, particularly older, admission.