Clinical characteristics, drug resistance and death risk factors of Burkholderia cepacia infection in hematopoietic stem cell transplant patients

• DOI: 10.1186/s12879-022-07754-z
• Publication Date: 2022-10-06T04:02:32Z
• Authors: Yan Jia; Ya Liu; Yi Liu; Kaitai Yang; Yanfeng Liu
• Keywords: Univariate analysis

Abstract Background Burkholderia cepacia (BC) has been detected more and in infected patients recent years. However, as a high-risk population, the clinical characteristics prognosis of BC infection hematopoietic stem cell transplantation (HSCT) have not reported. The purpose this study is to obtain data that will help fill gaps field, provide evidence for reducing mortality rate HSCT patients, guide use antibiotics future. Methods Electronic medical records with who underwent Xiangya Hospital Central South University from September 1, 2015 August 31, 2021 were collected. At same time, 1:1 case–control matching was conducted according gender, age disease type. Comparisons between with/without respiratory failure made respectively, sensitivity five clinically commonly used also evaluated. Univariate multivariate analyses performed identify independent risk factors death. Results most common site lung (75%). Although (3.74%) antibiotic resistance significant, it closely associated higher death (P = 0.022), which even further increased 90.9% when combined 0.008). Procalcitonin > 10 µg/L (HR 40.88, 95% CI 6.51–256.63, P 0.000) septic shock 4.08, 1.02–16.33, 0.047) two Conclusion are critical condition, management should be especially strengthened improve these patients.