Systemic inflammatory response syndrome in patients with severe fever with thrombocytopenia syndrome: prevalence, characteristics, and impact on prognosis

• DOI: 10.1186/s12879-024-09026-4
• Publication Date: 2024-01-31T08:55:48Z
• Authors: Zhongwei Zhang; Xue Hu; Qunqun Jiang; Fangzhou Jiao; Qian Du; Jie Liu; Mingqi Luo; Anling Li; Liping Deng; Yong Xiong
• Keywords: Case fatality rate

Abstract Background Severe fever with thrombocytopenia syndrome (SFTS) is an emerging zoonosis a high fatality rate in China. Previous studies have reported that dysregulated inflammatory response associated disease pathogenesis and mortality patients SFTS. This investigation aimed to evaluate the prevalence characteristics of systemic (SIRS), its impact on prognosis. Methods Data demographic characteristics, comorbid conditions, clinical manifestations, laboratory parameters, survival time SFTS were collected. Patients divided into non-SIRS SIRS groups according presence SIRS, then their data compared. Results A total 290 diagnosed retrospectively enrolled, including 126(43.4%) SIRS. non-survivor group had more than survivor ( P < 0.001), (adjusted OR 2.885, 95% CI 1.226–6.786; = 0.005) was shown as independent risk factor for prognosis Compared without lower WBC neutrophils counts, fibrinogen levels, but higher AST, LDH, amylase, lipase, CK, CK-MB, troponin I, APTT, thrombin time, D-dimer, CRP, IL-6, SAA viral load. The cumulative significantly also showed incidence bacterial or fungal infections Conclusions highly frequent SFTS, it mortality.