Prevalence and outcomes of chronic comorbid conditions in patients with sepsis in Korea: a nationwide cohort study from 2011 to 2016

• DOI: 10.1186/s12879-024-09081-x
• Publication Date: 2024-02-12T10:02:23Z
• Authors: Christine Kang; Seongmi Choi; Eun Jin Jang; Somin Joo; Jae Hoon Jeong; Seung-Young Oh; Ho Geol Ryu; Hannah Lee
• Keywords: Chronic liver disease

Abstract Background Chronic comorbid conditions are common in patients with sepsis and may affect the outcomes. This study aimed to evaluate prevalence outcomes of comorbidities sepsis. Methods We conducted a nationwide retrospective cohort study. Using data from National Health Insurance Service Korea. Adult (age ≥ 18 years) who were hospitalized tertiary or general hospitals diagnosis between 2011 2016 analyzed. After screening all International Classification Diseases 10th revision codes for comorbidities, we identified hypertension, diabetes mellitus (DM), liver cirrhosis (LC), chronic kidney disease (CKD), malignancy as prevalent comorbidities. Results Overall, 373,539 diagnosed Korea 2016. Among them, 46.7% had 23.6% DM, 7.4% LC, 13.7% CKD, 30.7% malignancy. In-hospital mortality rates 25.5%, 25.2%, 34.5%, 28.0%, 33.3%, respectively, showing decreasing trend over time ( P < 0.001). adjusting baseline characteristics, male sex, older age, use mechanical ventilation, continuous renal replacement therapy, significantly associated in-hospital mortality. Conclusions Hypertension is most comorbidity sepsis, it an increased survival rate. Additionally, cirrhosis, disease, result higher than hypertension significant risk factors