Respiratory syncytial virus subtypes in children with bronchiolitis: does it correlate with clinical severity?

• DOI: 10.1186/s12879-024-09129-y
• Publication Date: 2024-02-26T16:02:39Z
• Authors: Shuo Yang; Sukun Lu; Yakun Wang; Yinghui Guo; Zhuang Zhang; Weijian Wang; Le Wang
• Keywords: 03 medical and health sciences; RSV subtypes; 0302 clinical medicine; Research; Bronchiolitis; Infectious and parasitic diseases; RC109-216; Children; Outcome

Abstract Background In this retrospective study, we aimed to evaluate the factors associated with the severity of respiratory syncytial virus (RSV) bronchiolitis in children aged under 2 years who were admitted to the Children’s Hospital of Hebei between June 2018 and January 2019.

Methods Sputum samples positive for RSV via multiplex PCR were subtyped using real-time PCR. Data collected included risk factors for disease severity, demographics, microbiology, and outcomes.

Results Of the 82 children with RSV bronchiolitis, 79 were treated and discharged with improvement, while 3 died. All three patients had underlying medical conditions, including complex congenital heart disease and severe combined immunodeficiency. Further, disease severity was associated with preexisting underlying disease, fever duration, and bacterial co-infection, but not with the RSV subtype.

Conclusions Our findings suggest that an appropriate therapeutic regimen should include the detection of bacterial co-infections and the identification of underlying diseases for the effective management of severe RSV bronchiolitis.