The association of polymorphisms of TLR4 and CD14genes with susceptibility to sepsis in a Chinese population

• DOI: 10.1186/s12881-014-0123-4
• Publication Date: 2014-11-13T18:01:53Z
• Authors: Haiyan Wang; Yesheng Wei; Yi Zeng; Yueqiu Qin; Bin Xiong; Gang Qin; Jun Li; Donghai Hu; Xiaowen Qiu; Suren R Sooranna; Liao Pinhu
• Keywords: Adult; Aged, 80 and over; Male; China; 0303 health sciences; Adolescent; Lipopolysaccharide Receptors; Sequence Analysis, DNA; Middle Aged; Polymorphism, Single Nucleotide; 3. Good health; Toll-Like Receptor 4; Young Adult; 03 medical and health sciences; Asian People; Haplotypes; Sepsis; Genetics; Humans; Genetics(clinical); Female; Genetic Predisposition to Disease; Research Article; Aged

Sepsis is now the leading cause of death in non-cardiovascular intensive care unit (ICU). Recent research suggests that sepsis likely to be due an interaction between genetic and environmental factors. Genetic mutations toll-like receptor 4 (TLR4) cluster differentiation 14 (CD14) genes are involved immune (or) inflammatory response. These may contribute susceptibility patients. This study was designed evaluate whether TLR4 CD14 gene polymorphisms associated with sepsis. The single nucleotide (SNPs) (rs10759932, rs11536889, rs7873784, rs12377632, rs1927907, rs1153879) (rs2569190 rs2563298) patients control subjects Guangxi Province were analyzed by using polymerase chain reaction-single base extension (PCR-SBE) DNA sequencing methods. rs11536889 polymorphism rs2563298 significantly risk when compared group. frequencies group higher than (OR = 1.430, 95% CI, 1.032-1.981, P<0.05; OR 2.454, 1.458-4.130, P<0.05, respectively). Followed up haplotype analysis suggested there two haplotypes which increased factors for indicated. CD14,