Comparison of single CT scan assessment of bone mineral density, vascular calcification and fat mass with standard clinical measurements in renal transplant subjects: the ABC HeART study

• DOI: 10.1186/s12882-015-0182-6
• Publication Date: 2015-11-11T12:11:18Z
• Authors: Sinead Kinsella; Kevin Murphy; Micheal Breen; Siobhan O’Neill; Patrick McLaughlin; Joe Coyle; Conor Bogue; Fiona O’Neill; Niamh Moore; AnneMarie McGarrigle; Michael G. Molloy; Michael M. Maher; Joseph A. Eustace
• Keywords: Densitometry

Despite limitations of routine methods, Clinical Practice Guidelines support the assessment bone mineral density (BMD) and vascular calcification in renal transplant recipients. Changes fat mass also occur post-transplantation, although they are traditionally difficult to measure accurately. We report feasibility, convenience accuracy measuring above 3 parameters using a novel CT protocol. conducted cross-sectional study 64 first allograft recipients (eGFR > 30 ml/min/1.73 m2). Quantitative (QCT) BMD analysis was lumbar spine (GE Medical Systems Lightspeed VCT & Mindways QCT Pro Bone Mineral Densitometry System Version 4.2.3) calculate spinal volumetric compared with standard DXA calculated areal at spine, hip distal forearm. Abdominal aortic assessed by semi-quantitative Aortic Calcification Index (ACI) method lateral x-ray Kappuila score pulse wave velocity (PWV). Visceral subcutaneous adipose tissue volume (Osirix 16 Ver 3.7.1) BMI. Participants were 61 % male, had mean age 47 years, median ESKD duration 5.4 years eGFR 54 ml/min. iDXA T-score proximal femur −1.2 −0.2. Median Trabecular −1.2. The percent subjects <2.5 site Proximal Femur: 7 %, radius: 17 spine: 9 (American College Radiology cutoffs): %. derived ACI correlated PWV (r = 0.29, p 0.02), pressure 0.51, < 0.001), (−0.31, 0.01) cortical history cardiovascular events (Mann–Whitney U, 0.02). Both visceral BMI 0.63 0.64, 0.001). Single scan triple BMD, body composition is an efficient, accurate convenient risk factor monitoring post transplantation.