The Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equation does not improve the underestimation of Glomerular Filtration Rate (GFR) in people with diabetes and preserved renal function

• DOI: 10.1186/s12882-015-0196-0
• Publication Date: 2015-12-02T23:34:22Z
• Authors: Richard J. MacIsaac; Elif I. Ekinci; Erosha Premaratne; Zhong X. Lu; Jas-mine Seah; Yue Li; Ray Boston; Glenn M. Ward; George Jerums
• Keywords: Nephrology

Our hypothesis was that both the Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) and Modification of Diet in Renal Disease (MDRD) equations would underestimate directly measured GFR (mGFR) to a similar extent people with diabetes preserved renal function.In cross-sectional study, bias (eGFR - mGFR) compared for CKD-EPI MDRD equations, after stratification mGFR levels. We also examined ability equation correctly classify subjects various CKD stages. In longitudinal study an early decline i.e., initial > 60 ml/min/1.73 m(2) rate (ΔmGFR) 3.3 per year, ΔmGFR (based on final values) ΔeGFR by over mean 9 years.In whole group 80 ± 2.2 (n = 199, 75 % type 2 diabetes). For >90 (mGFR: 112 2.0, n 76), significantly underestimated extent: CKD-EPI: -12 1.4 (p < 0.001) MDRD: -11 2.1 0.001). Using did not improve number were classified CKD-stage. No biochemical or clinical patient characteristics identified account under estimation values normal high range equation. 30, 66 1 diabetes), 102.8 6 54.6 6.0 m(2), respectively. Mean ΔGFR (ml/min/1.73 year) only 3.0 3.2 (both p 0.05 vs CONCLUSIONS: Both reference 90 as well diabetes. There is scope methods estimating GFR.