Risk factors for infectious complications of ANCA-associated vasculitis: a cohort study

• DOI: 10.1186/s12882-018-0933-2
• Publication Date: 2018-06-14T08:35:05Z
• Authors: Liu Yang; Honglang Xie; Zhengzhao Liu; Yinghua Chen; Jinquan Wang; Haitao Zhang; Yongchun Ge; Weixin Hu
• Keywords: Vasculitis; Adult; Male; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Antibodies, Antineutrophil Cytoplasmic; Cohort Studies; 03 medical and health sciences; 0302 clinical medicine; Risk Factors; Pneumonia, Bacterial; Humans; Lung; Aged; Retrospective Studies; Middle Aged; Diseases of the genitourinary system. Urology; Anti-neutrophil cytoplasmic antibody; 3. Good health; Risk factors; Female; RC870-923; Infection; Immunosuppressive Agents; Research Article; Follow-Up Studies

Severe infections are common complications of immunosuppressive treatment for antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) with renal involvement. We investigated the clinical characteristics and risk factors severe infection in Chinese patients AAV after therapy. A total 248 a new diagnosis ANCA-associated were included this study. The incidence, time, site, by induction therapies analysed. Multivariate Cox proportional hazards models used to calculate hazard ratios (HRs) 95% confidence intervals (CI). 103 episodes identified 86 (34.7%, 86/248) during median follow-up 15 months. incidence therapy was 38.5% corticosteroids (CS), 39.0% CS+ intravenous cyclophosphamide (IV-CYC), 33.8% mycophenolate mofetil 22.5% CS + tripterygium glycosides, 76 (73.8%) occurred within 6 months, while 66 (64.1%) 3 Pneumonia (71.8%, 74/103) most frequent type infection, main pathogenic spectrum bacteria (78.6%), fungi (12.6%), viruses (8.7%). associated age at time (HR = 1.003, CI 1.000–1.006), smoking 2.338, 1.236–4.424), baseline secrum creatinine (SCr) ≥5.74 mg/dl 2.153, 1.323–3.502), CD4+ T cell< 281 μl 1.813, 1.133–2.900), regimen 1.951, =1.520–2.740). Twelve (13.9%) died pneumonia. rate high AAV. Bacterial pneumonia encountered. Age diagnosis, smoking, SCr mg/dl, μl, IV-CYC as infection.