The association between cognition and gait disturbance in central nervous system demyelinating disorder with mild disability

• DOI: 10.1186/s12883-023-03210-w
• Publication Date: 2023-04-29T05:01:41Z
• Authors: Min Cheol Chang; Byung Joo Lee; Dongseok Yang; Chung Reen Kim; Donghwi Park; Sunyoung Kim
• Keywords: Gait Disturbance; Depression; Movement Disorders

Gait disturbance in central nervous system (CNS) demyelinating disorders, including multiple sclerosis (MS) and neuromyelitis optica (NMO) is one of the most troublesome problems that has a direct impact on quality life. However, associations between gait other clinical variables these two diseases have not been fully elucidated.This study aimed to evaluate using computerized analysis its association with various patients MS NMO.A total 33 (14 19 NMO) minor disabilities, who were able walk independently had passed their acute phase, enrolled study. performed computer-based instrumented walkway system. (Walk-way MG-1000, Anima, Japan) Clinical variables, such as disease duration, medication, body mass index (BMI), hand grip power, muscle recorded. The Montreal Cognitive Assessment (MOCA), Beck Depression Inventory score-II (BDI), fatigue scale measured Functional Chronic Illness Therapy-fatigue (FACIT-fatigue) scale. A trained neurologist scored Expanded Disability Status Scale (EDSS).Gait speed was single parameter showed significant positive correlation MOCA (p < 0.001). stance phase time negative EDSS Hand strength skeletal assessed by bioimpedance 0.05). FACIT-fatigue score BDI 0.001).In our MS/NMO mild disability, cognitive impairment significantly correlated speed, degree disability time. Our findings may imply early detection decrease an increase can predict progression disability.