Postoperative complications affect early recurrence of hepatocellular carcinoma after curative resection

Adult Male Cancer Research Carcinoma, Hepatocellular Young Adult 03 medical and health sciences Postoperative Complications 0302 clinical medicine Risk Factors Genetics Odds Ratio Hepatectomy Humans Aged Retrospective Studies Aged, 80 and over Liver Neoplasms Middle Aged 3. Good health Treatment Outcome Oncology Female Neoplasm Recurrence, Local Research Article
DOI: 10.1186/s12885-015-1720-0 Publication Date: 2015-10-14T10:08:17Z
ABSTRACT
Postoperative recurrence remains the major cause of death after curative resection for hepatocellular carcinoma (HCC). This study was conducted to evaluate the impact of postoperative complications on HCC recurrence after curative resection.The postoperative outcomes of 274 HCC patients who underwent curative resection were analysed retrospectively.Of the 247 HCC patients, 103 (37.6 %) patients developed postoperative complications. The occurrence of postoperative complications was found to be associated with a significantly higher tumor recurrence (76.2 % vs. 56.6 %, P = 0.002) and a lower 5-year overall survival rate (27.7 % vs. 42.1 %; P = 0.037) as compared with those without complications. Regarding the recurrence pattern, early recurrence (≤2 years) was more frequently seen in patients with complications than that in patients without complications (54.5 % vs.38.6 %; P = 0.011). Multivariate analysis indicated that postoperative complications occurrence was an independent risk factor for early recurrence (odds ratio [OR] 2.223; 95 % confidence intervals [95 % CI] 1.161-4.258, P = 0.016) and poor overall survival (OR 1.413; 95 % CI, 1.012-1.971, P = 0.042).The results of the present study indicate that the occurrence of postoperative complications is a predictive factor for HCC recurrence after curative hepatectomy, especially for early recurrence.
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