High plasma adiponectin is associated with increased pulmonary blood flow and reduced right ventricular function in patients with pulmonary hypertension

• DOI: 10.1186/s12890-020-01233-4
• Publication Date: 2020-07-30T11:28:24Z
• Authors: Dongling Luo; Pengyuan Chen; Ziyang Yang; Yongheng Fu; Yigao Huang; Hezhi Li; Jimei Chen; Jian Zhuang; Caojin Zhang
• Keywords: Brain natriuretic peptide

Abstract Background Adiponectin is a biomarker closely related to heart failure. However, its role in pulmonary hypertension remains unclear. In this study, we investigated the association between adiponectin and hemodynamic abnormalities, right ventricular function patients with congenital disease associated (CHD-PH). Methods Patients CHD-PH were enrolled cross-sectional study. Linear regression analysis was performed assess adiponectin, N-terminal pro-Brain Natriuretic Peptide (NT-proBNP) different clinical parameters. Results depicted as beta-estimates(ß) 95%-confidence intervals (95% CI). addition, mediation receiver operating characteristic curve analyses used analyze relationships among NT-proBNP function. A total of 86 included. The overall mean concentration 7.9 ± 5.8 μg/ml. Log positively correlated circulation index (ß = 2.2, 95% CI 0.5, 4.0), log 0.22, 0.04, 0.41) inversely tricuspid annular plane systolic excursion (TAPSE, ß -4.7, -8.6, − 0.8). revealed TAPSE fully mediated by (total effect c 5.4, -9.4, 1.5, p 0.013; direct c’ 3.7, -7.5, 0.1, 0.067). Additionally, efficiency for detecting dysfunction not inferior (AUC 0.84, 0.67–1.00 vs AUC 0.74, 0.51–0.97, 0.23). Conclusions blood flow may be valuable assessment hypertension.