Association of monoaminergic gene polymorphisms in chronic inflammatory pulmonary disease patients with successful smoking cessation

• DOI: 10.1186/s12890-024-03219-y
• Publication Date: 2024-08-26T14:03:09Z
• Authors: Angela Mikaczo; Csaba Papp; Tamas Erdei; Aniko Posa; Gabor Zahuczky; Csaba Varga; Janos Szabo; Rudolf Gesztelyi; Maria Szilasi; Judit Zsuga
• Keywords: rs4680; Minor allele frequency

Abstract Background Albeit smoking cessation has unequivocal health benefits, attempts to quit are not unanimous, even in patient populations at high risk for smoking-related diseases cessation. Allelic variations of enzymes involved dopamine metabolism being considered as candidates nicotine addiction. We set out assess whether rs4680 G/A and rs2235186 polymorphisms COMT MAO-A, respectively associated with the ability chronic inflammatory pulmonary disease patients. Methods Patients managed by Department Pulmonology (University Debrecen, Hungary), a current or past habit were included analysis. The study was designed line STROBE statement cross-sectional studies approved National Center Public Health, Hungary. Genomic DNA extracted from peripheral blood specimens. SNPs genotyped using TaqMan SNP genotyping assays. Results polymorphism showed significant effect successful patients disease. Accordingly, A/A subjects had lower odds (odds ratio 0.37; 95% confidence interval 0.20–0.69, p = 0.002 (additive model). On other hand, homozygous minor allele (A) MAO-A non-significant trend toward increased Conclusions presence shown decrease cessation, finding that may be interpreted view altered balance between tonic phasic release.