Perioperative risk factors in patients with a femoral neck fracture – influence of 25-hydroxyvitamin D and C-reactive protein on postoperative medical complications and 1-year mortality

• DOI: 10.1186/s12891-016-0906-1
• Publication Date: 2016-02-01T16:46:43Z
• Authors: Johannes KM Fakler; Antonia Grafe; Jamila Dinger; Christoph Josten; Gabriela Aust
• Keywords: Hip Fracture

This study examined the association of 25-hydroxyvitamin D (25(OH)D) and C-reactive protein (CRP) with postoperative medical complications one year mortality elderly patients sustaining a low-energy cervical hip fracture scheduled for surgery. We hypothesized that vitamin deficiency CRP in these might be associated an increased 1-year mortality. The prospective single-center cohort included 209 medial femoral neck fracture; 164 women aged over 50 years 45 men 60 years. Referring to multiple logistic regression analysis including 10 co-variables (age, sex, BMI, ASA, creatinine, CRP, leukocytes hemoglobin, 25(OH)D, supplementation at follow-up) was performed. Vitamin prevalent 87 % all patients. In severe (<10 ng/ml) moderate (10–20 29 13 %, respectively, compared 9 > 20 ng/ml 25(OH)D levels (p =0.027). Patients mild (CRP 10–39.9 mg/l) or active inflammatory response ≥ 40 showed higher 33 16 no < = 0.002). Multiple identified (OR 1.01, 95 CI 1.00-1.02; p 0.007), but not 0.97, 0.89-1.05; 0.425) as independent predictor suffered in-hospital (i.e. pneumonia, thromboembolic events, etc.). 0.89, 0.81–0.97; 0.010), 0.139), risk factor. fracture, is independently