A study of the factors associated with cervical spinal disc degeneration, with a focus on bone metabolism and amino acids, in the Japanese population: a cross sectional study

• DOI: 10.1186/s12891-018-2055-1
• Publication Date: 2018-05-17T12:26:53Z
• Authors: Kanichiro Wada; Toshihiro Tanaka; Gentaro Kumagai; Hitoshi Kudo; Toru Asari; Daisuke Chiba; Seiya Ota; Keita Kamei; On Takeda; Shigeyuki Nakaji; Yasuyuki Ishibashi
• Keywords: Intervertebral Disc; Degeneration (medical)

The physical and biochemical factors responsible for cervical disc degeneration, resulting in various spinal disorders, remain unclear. This study aimed to evaluate the correlation between canal stenosis degeneration of intervertebral discs, analyze related Japanese population.Three hundred forty-four general residents underwent investigations, including magnetic resonance imaging spine, our health check project. We measured anteroposterior diameters at levels mid sagittal plane evaluated degeneration. Spearman coefficient was used whether were correlated with degenerative scores. Stepwise multiple linear regression analysis conducted score as dependent variable; age, measurement values, bone mineral density forearm, value serum metabolic markers amino acids independent variables each sex.As age increased, decreased both sexes. minimum scores (Spearman r = - 0.59, p < 0.001 men, 0.53, women). In analysis, cross-linked N-telopeptide type 1 collagen isoleucine significantly men (R2 0.47), lysine women 0.50).The differed women. Whether modifying these significant is possible, or this intervention would contribute prevention requires future studies.