A magnesium calcium phosphate-based cement as a bone adhesive: characterization and biomechanical evaluation

• DOI: 10.1186/s12891-025-08498-y
• Publication Date: 2025-03-14T06:54:47Z
• Authors: Philipp Heilig; Sina Ritzmann; Maximilian Heilig; Martin Cornelius ...; Rainer Heribert M...; Uwe Gbureck; Stefanie Hoelsche...
• Keywords: Magnesium phosphate; Osteosynthesis

Abstract Background Usually, comminuted fractures contain fragments that are too small for fixation with Kirschner (K)-wires or screws. For those bony osteochondral fragments, a bone adhesive would be desirable to, example, enable easy anatomic reduction, avoid discarding of the and temporary to visualize reduction before definitive osteosynthesis is performed. Most currently available adhesives have shortcomings, such as cytotoxicity, lack resorbability, inadequate mechanical properties. Thus, there room improved adhesives. The present work involves synthesis, characterization, biomechanical evaluation three variants novel magnesium calcium phostphate-based cement may used adhesive. Methods Three experimental formulations phosphate-based commercially-available cyanoacrylate (Glubran ® 2) were used. phosphate (Mg 3 PO 4 + MgO phytic acid) (MPC_25), 2.75 Ca 0.25 (MPCa_22.5), had undergone modified temperature stages during sintering O 8 P 2 * x H O) (HT-MPC). In vitro quasi-static compression tests conducted using cuboid specimens. Split lateral tibial plateau created in dissected porcine tibiae. fracture glued onto condyles. Load was applied on via femoral component knee hemiarthroplasty. Cyclic loading increasing load levels, load-to-failure tests, torque this model. Results Among formulations, HT-MPC highest compressive strength (26.8 ± 9.5 MPa), MPCa_22.5 cyclic (162 40 N) (295 84 N), while calculated shear obtained both MPC_25 (0.27 0.12 0.26 0.06 MPa, respectively), torque-to-failure (2.2 0.8 2.1 1.2 Nm, respectively). (0.13–0.38 MPa) above minimum has been suggested required clinical practice (0.2 MPa). Relative Glubran significantly lower, but each other four parameters, values higher. Conclusions Each synthesized adequate strength, resistance fatigue failure. merits further study use intraoperative fragments.