Comparison of thyroid function in different emotional states of drug-naïve patients with bipolar disorder

• DOI: 10.1186/s12902-021-00869-5
• Publication Date: 2021-10-21T12:02:36Z
• Authors: Shengnan Zhao; Xu Zhang; Yaling Zhou; Hao Xu; Yuwei Li; Yuexin Chen; Bo Zhang; Xueli Sun
• Keywords: Hypothalamic–pituitary–thyroid axis; Thyroid-stimulating hormone

Abstract Background Previous studies have shown that bipolar disorder is closely related to thyroid dysfunction. Psychiatric drugs a large or small effect on function, and hormone levels can also affect the of drug treatment. Therefore, purpose this study assessment function drug-naive across different mood states, with expectation providing support for treatment options. Methods The present cross-sectional study. Patients diagnosed according International Classification Diseases diagnostic Criteria, Edition 10 (ICD 10) who had never received medication were included in Montgomery Depression Scale (MADRS) was used assess depressive symptoms Young Mania Rating (YMRS) manic symptoms. Thyroid indicators include thyroid-stimulating (TSH), free triiodothyronine (FT3), total (TT3), thyroxine (FT4), (TT4). Levels TSH, TT4, FT4, TT3, FT3 measured within 48 h hospitalization, between 06:00 08:00. Results data analysis finally covered 291 subjects (136 group, 128 27 mixed group), including 140 males 151 females, an average age 27.38 ± 8.01. There no significant difference age, sex, marital status, work family history, course illness among group. level FT3, rate increased secretion, abnormality secretion group significantly higher than those Conclusion These findings indicate functions episodes BD patients. In clinical practice, it necessary take into account differences patients emotional states choosing drug.