Serum stromal cell-derived factor-1 concentrations are increased and associated with nonalcoholic fatty liver disease in children with obesity

• DOI: 10.1186/s12902-024-01597-2
• Publication Date: 2024-05-10T10:01:43Z
• Authors: Yuesheng Liu; Lijun Hao; Linhao Wang; Mengnan Lu; Chunyan Yin; Yanfeng Xiao
• Keywords: Male; Pediatric Obesity; 0303 health sciences; Adolescent; Research; RC648-665; Diseases of the endocrine glands. Clinical endocrinology; Chemokine CXCL12; SDF-1; Body Mass Index; 03 medical and health sciences; Non-alcoholic Fatty Liver Disease; Case-Control Studies; Nonalcoholic fatty liver disease; Humans; Female; Childhood obesity; Insulin Resistance; Child; Biomarkers

Abstract Introduction Stromal cell-derived factor-1 (SDF-1) is a newly discovered small molecule adipocytokine, and research has shown that it is closely related to the occurrence and development of obesity. However, there are currently few research reports on SDF-1 in childhood obesity and nonalcoholic fatty liver disease (NAFLD), and this study aims to explore the relationship between SDF-1 and obesity related indicators in obese children.

Methods Serum SDF-1 concentrations were measured using enzyme-linked immunosorbent assay (ELISA). Clinical and biochemical data were collected, such as body mass index (BMI), waist and hip circumference, blood pressure, liver enzymes, cholesterol, and fasting insulin. Children with NAFLD or not were evaluated through Color Doppler Ultrasound.

Results Serum SDF-1 concentrations were significantly higher in obese subjects than in non-obese subjects (P < 0.05), and were elevated in the NAFLD obese subjects than in the non-NAFLD obese subjects (P < 0.05). SDF-1 was positively correlated with BMI, waist-to-hip ratio, systolic blood pressure, body fat percentage (BFP), basal metabolic rate (BMR), alanine transaminase (ALT), aspartate transaminase (AST), glutyltranspeptidase (GT), and homoeostasis model of HOMA-IR, independent of their uric acid (UA), total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), gender and age. BFP and BMR were associated with the serum SDF-1 concentrations in multivariable linear regression analysis.

Conclusion These results suggest that SDF-1 levels are elevated in obese children and are associated with NAFLD, indicating that SDF-1 may play a role in the development of childhood obesity and metabolic disorders.