Salivary and serum inflammatory mediators among pre-conception women with periodontal disease

• DOI: 10.1186/s12903-016-0306-9
• Publication Date: 2016-12-15T16:22:31Z
• Authors: Hong Jiang; Yiming Zhang; Xu Xiong; Emily W. Harville; Karmin O; Xu Qian
• Keywords: Dentistry(all); Interleukin-6; Tumor Necrosis Factor-alpha; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Pregnancy; Gingival Diseases; Humans; Female; Inflammation Mediators; Periodontitis; Saliva; Periodontal Diseases; Research Article

There have been inconsistent conclusions regarding the levels of inflammatory mediators in saliva and serum among people with or without periodontal disease. Although pre-conception has put forward as optimal time for treatment order to improving pregnancy outcomes, few studies conducted examine women. Pre-conception women were recruited between January 2012 December 2014. Women provided an oral health examination detect Salivary samples collected at same examination. Inflammatory includinginterleukin-1 beta (IL-1β), IL-6, tumor necrosis factor alpha (TNF-α) beta-glucuronidase (β–glucuronidase) tested analyzed overall disease (n = 442) moderate/severe 247). Results compared that a healthy periodontium 91). Significantly increased concentrations IL-1β, TNF-α β-glucuronidase found disease, also all above IL-1β The almost except IL-6 significantly severity Periodontal is highly associated elevated some